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Splice variants of human IL-23 receptor (IL-23R) mRNA and use of a Δ9 isoform in predicting inflammatory bowel diseases
Splice variants of human IL-23 receptor (IL-23R) mRNA and use of a Δ9 isoform in predicting inflammatory bowel diseases
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机译:人IL-23受体(IL-23R)mRNA的剪接变体和Δ9亚型在预测炎症性肠病中的应用
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摘要
There is disclosed the cloning and identification of human IL-23R splice variants caused by alternative splicing of the IL-23R mRNA in human. Alternative mRNA forms occur through skipping one, multiple full exons or partial exons, within the IL-23R gene. A total of twenty-five (25) different IL-23R transcripts were identified. A novel exon deletion (exon 9) isoform in the interleukin 23 receptor is disclosed, denoted as Δ9. The present application also describes a quantitative assay to measure different IL-23R isoform. Detection of Δ9 isoform of IL-23R is predominantly present in colon and cervical tissues. A decrease in Δ9 is observed in inflamed colon tissues in Crohn's patients. There is disclosed a method of predicting Crohn's disease by measuring Δ9 isoform of IL-23R.
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