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Methods for diagnosing and treating CNS disorders by trans-blood-brain barrier delivery of protein compositions
Methods for diagnosing and treating CNS disorders by trans-blood-brain barrier delivery of protein compositions
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机译:通过跨血脑屏障蛋白组合物诊断和治疗中枢神经系统疾病的方法
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摘要
The invention provides methods for treating or diagnosing CNS disorders by systemic administration of therapeutic or diagnostic protein compositions that are capable of crossing the blood-brain barrier, in some embodiments in both directions, while allowing their activity once across the barrier to remain substantially intact. The agents are transported across the blood-brain barrier via one or more endogenous receptor-mediated transport systems. Also provided are methods for manufacturing the compositions used in the methods described herein.
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