Fluorescent substrates for monoamine transporters as optical false neurotransmitters

摘要

The present invention relates to compounds of the general structure: wherein Y is O, X is O, bond α is absent and bond β is present, or Y is H, X is CH, bond α is present, and bond β is absent; atom Z is a carbon and bonds χ, δ and γ are present, or is a nitrogen and bonds χ, δ and γ are absent; R₁ is —H, —OH, —O—R₇, —N(H)—R₈, —N(H)—(CH₂)_n—NH₂, —N(R₉)(R₁₀), or a piperazine cation; R₂ is either covalently bound to R₉, or is —H, or is covalently bound to R₃ so as to form a substituted or unsubstituted pyrrole or R₂ is covalently bound to R₉ or R₈ or R₇; or R₁ and R₂ are covalently joined to form an aromatic ring; R₃ is either covalently bound to R₂ so as to form a pyrrole, or is, inter alia, —H, —OH, alkyl, or when Z is nitrogen R₃ is ═O; R₄ is, inter alia, —H, —OH, or —R₁₁NH₂; R₅ is, inter alia, —H, —OH, or —R₁₂NH₂, and R₆ is either is covalently bound to R₁₀ or is —H, or R₆ is covalently bound to R₁₀ or R₈ or R₇. This invention also provides processes for making the compounds as well as methods for monitoring activity of monoamine transporters or treating monoamine transporter-associated diseases by employing the compounds.;