Processes for preparing pharmaceutical grade melphalans from industrial grade reactants

摘要

A four stage inexpensive method of preparing pharmaceutical grade Melphalans of Melphalan 2-HCl, Melphalan HCl and Melphalan by:reacting N-phthaloyl-4-[bis(2-hydroxyethyl)amino]-phenylalanine ethyl ester with phosphorous oxychloride, reacting the chlorinated product with HCl and alkali hydroxide and purifying, and lyophilizing to obtain Melphalans.