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Duplex oligonucleotides with enhanced functionality in gene regulation
Duplex oligonucleotides with enhanced functionality in gene regulation
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机译:具有基因调控功能增强的双链寡核苷酸
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摘要
Disclosed are methods of enhancing functionality of duplex oligonucleotides and compositions made by the methods. The duplex oligonucleotides include siRNAs, miRNA mimics, and piRNA mimics which contain modified nucleotides and mismatches between the two strands of the molecule at specific nucleotide positions.
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