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Fusion Protein of Protein fragments to create compositions of natural human immunoglobulin FC multimerizadas orderly

机译:融合蛋白片段,有序地形成天然人免疫球蛋白FC multimerizadas的成分

摘要

A series of recombinant immunoglobulins In this way, the immunoglobulin (FC) multivalent appears on the receptor of immune cells. Fusion proteins exist as highly clean homogeneous and polycrystalline parts, called stradomers (biomolecules). Compared with the homogeneous part, the pure multiamerican stradomers have stronger affinity, enthusiasm and lower dissociation with fcgrs (FCG receiver),They are useful in the treatment and prevention of diseases. It has been proved that the direct combination of FC area and multi beautification field of the global biodiversity and Ecological Management Institute 1 has led to greater multi beautification and biological activities. A treatment for inflammation, autoimmune disease, or infectious disease. A way to prevent the binding of nonspecific in vitro or preactive antibodies One way to reduce the endocrine level: component 1: a unit of stratomer, which is characterized by (a) an instruction sequence, (b) a partial domain of IgG1, and (c) a multiple domain,Among them, the instruction sequence is directly connected to the Fc domain of IgG1, while the Fc domain of IgG1 is directly connected to the multi-functional domain.
机译:一系列重组免疫球蛋白这样,免疫球蛋白(FC)多价出现在免疫细胞的受体上。融合蛋白以高度纯净的均质多晶部分存在,称为顺式异构体(生物分子)。与均质部分相比,纯的美国多聚体具有更强的亲和力,热情和与fcgrs(FCG受体)的离解率低,可用于治疗和预防疾病。事实证明,全球生物多样性和生态管理研究所1的FC区域和多种美化领域的直接结合导致了更多的多种美化和生物活动。炎症,自身免疫性疾病或传染病的治疗方法。一种防止与非特异性体外抗体或活性前抗体结合的方法降低内分泌水平的一种方法:组分1:扼杀者的单位,其特征在于(a)指令序列,(b)IgG1的部分结构域,和(c)多结构域,其中,指令序列直接与IgG1的Fc结构域相连,而IgG1的Fc结构域与多功能结构域直接相连。

著录项

  • 公开/公告号AR082404A1

    专利类型

  • 公开/公告日2012-12-05

    原文格式PDF

  • 申请/专利权人 GLIKNIK INC.;

    申请/专利号AR2011P102729

  • 发明设计人 OLSEN HENRIK;BLOCK DAVID S.;

    申请日2011-07-28

  • 分类号C07K16/46;A61K39/395;A61P29;A61P31;A61P37/06;C12P21/02;

  • 国家 AR

  • 入库时间 2022-08-21 16:42:31

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