Use of nucleoside and nucleotide analogues to treat Viral Infections and / or paramyxovirus Orthomyxovirus, related compounds and Pharmaceutical compositions containing them

摘要

1. Claim 1: number of effective treatments using a formula compound (1),Or a pharmaceutically acceptable salt for the preparation of a drug for the improvement or treatment of a virus infection selected for parasite virus infection or orthopedic virus infection, in which the compound of formula (1) has a structure and B1A is selected from a base group. a. Selective substitution of heterocyclic ring and selective heterocyclic group by protected Amin group; R1a was selected from hydrogen group, alternative acid or formula group (2);Na is 0, 1 or 2; R2A and R3a are independent of hydrogen group, an alternative C1-6 tar and an alternative C1-6 halide substitute; R4A is selected from the group consisting of hydrogen, halogen and a alternative C1-6 tar (= O) R19A; R5a is selected from hydrogen, halogen, C1-6 alternative tar groups, - or20a and - OC (= O) r21a; r6a is selected from hydrogen, halogen, C1-6 alternative tar groups, - Or22a and - OC (= O) r23a; or r5a and r6a are two oxygen atoms and are combined by one carbon group;R7a is selected from the group consisting of hydrogen, halogen, a selective alternative C1-6 tar (= or24a and - OC (= O) r25a); R8a is selected from the group consisting of hydrogen, a selective alternative C1-6 tar and a selective alternative C1-6 halotar; r9a and r12a are either absent or hydrogen; R10a does not exist or is hydrogen; each r11a does not exist or is hydrogen independently; r13a does not exist or is hydrogen; r14a is selected from a group consisting of an alternative arilo, an alternative alien arilo and an alternative heterocycle,R15a is an alternative amino acid linker or an alternative amino acid linker derivative, or r14a is an alternative amino acid linker or an alternative amino acid linker derivative, R15a is an amino acid associated with alternative n or an amino acid derivative associated with alternative n; or r14a is an O -,Hydrogen Xi or un-o-asphalt C1-6 can be replaced optionally, r15a and r5a together are o; r16a is selected from a group consisting of an alternative arilo, an alternative heterosexual and an alternative heterosexual, R17a is an alternative amino acid and n-complex or an alternative amino acid derivative; or r16a is an alternative amino acid and n-complex or an alternative amino acid derivative, R17a is an amino acid that can selectively replace n or an amino acid derivative that can selectively replace n; or r16a is an O -,Hydrogen Xi or un-o-asphalt C1-6 can be replaced, r17a and r5a together are o; r18a, r20a, r22a and r24a are independent hydrogen or C1-6 alternative aspha R19A, r21a, The selection of r23a and r25a is independent of a group consisting of a selectively substituted C1-6 tar and a selectively substituted C3-6 cyclic Gaul tar.