1,3-Oxathiolan nucleoside analogues, pharmaceutical composition containing 1,3-oxathiolan nucleoside analogues and method of treatment of the viral infections

摘要

The invention relates to the 1,3-oxathiolan nucleoside analogues and use thereof in the treatment of viral infections. Summary of the invention consists in the fact that (-)-(cis)-4-amino-5-fluor-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidine-2-one represented by an absolutely stereochemical formula: CHFORM and pharmaceutically acceptable derivatives thereof possesses a far greater antiviral activity and a suddenly low toxicity in comparison with the corresponding (+)-enantiomer. The present compound and pharmaceutically acceptable derivatives thereof with an essentially free content of (+)-enantiomer can be used both in pure state and in compositions with pharmaceutically acceptable carriers and optionally with other therapeutical agents. Claims: 24