endothelial differentiation gene subfamily 3 receptor antagonists (edg-3, s1p3) for the prevention and treatment of eye diseases, compositions comprising said antagonists, and uses thereof

摘要

ANTEGONISTS OF SUBFAMILY 3 RECEPTORS (EDG-3, S1P3) OF ENDOMETAL DIFFERENTIATION GENE FOR THE PREVENTION AND TREATMENT OF EYE DISEASES, COMPOSITIONS UNDERSTANDING THESE ANTAGONISTS, AND USES THEREOF. The present invention relates to S1P3 receptor antagonists (Edg-3) for attenuating Smad signaling in a method of down-regulating receptor receptor signaling and reduced downstream production of connective tissue growth factor in occult diseases. involve accumulation of CTGF. Eye diseases involving inadequate accumulation of CTGF include ocular hypertension, glaucoma, glaucomatous retinopathy, optic neuropathy, macular degeneration, diabetic retinopathy, choroidal neovascularization, proliferative vitreoretinopathy and conceal healing, for example. Such diseases are treated by administering the antagonists of the present invention.