Peptu00cddeos markers of clinical stages of neurocysticercosis

摘要

Peptu00cddeos markers of clinical stages of neurocysticercosis. The present invention relates to the use of new peptides mimetics and reasons which have interactions with protein or specific immunoglobulin G antibodies in immunological diagnosis of neurocysticercosis to disease, in particular the inactive phase.To do so, have been selected peptides expressed on phages binding to serum immunoglobulin IgY White Leghorn chickens immunized with a saline extract of total metacestu00f3deos Taenia solium.The peptides that specifically called tr-lgy of immunised animals were selected and used for the detection of LGG in serum of human patients with neurocysticercosis through immunological test, ELISA (enzyme Iinked Immuno Assay). Among these patients, showed the active form of the disease, with cisticercos viable and part to form inactive, with cisticercos calcified.Our test with the peptides expressed on the phage resulted in a diagnosis of neurocysticercosis phases well need, obtained in a practical way by ELISA test. Due to the binding capacity of protein specific serologic to disease, these peptides may potentially be used in imunodiagnu00f3stico kits for differentiation of stages of neurocysticercosis.