processes for obtaining dithiocarbazate coordination complexes. coordination complexes containing transition metals, pharmaceutical compositions and their uses

摘要

PROCEDURES FOR OBTAINING DIICOCARBATE COORDINATION COMPLEXES, COORDINATION COMPLEXES CONTAINING TRANSITION METALS, PHARMACEUTICAL COMPOSITIONS AND THEIR USES. The present invention is intended for processes for obtaining dithiocarbazate coordination complexes, transition metal-containing coordination complexes such as: [M (L) (PR ~ 3 ~) (O) n (X) p] and / or of the type [M (O) n (L) (HL) q (RO (H) m) r], where M is preferably platinum, palladium, vanadium, rhenium and / or molybdenum, n = O, 1 or 2, q = O or 1, p = O or 1, m = O or 1, r = O or 1, X = halides and L = dithiocarbazate anion, derived from the deprotonation of H2L1 or H ~ 2 ~ L1, and pharmaceutical and / or veterinary compositions containing said coordinating complexes. Additionally, the present application addresses the uses of the dithiocarbazate-type compounds H ~ 2 ~ L1 and H ~ 2 ~ L2 and their coordination complexes in the preparation of medicaments, indicated as chemoprophylactic agents, capable of inhibiting the growth of the Trypanosoma cruzi parasite. treatment of Chagas disease in humans and / or animals.