首页> 外国专利> Isolated Antibody that binds to beta Amyloid Peptide Derivative of cyclic Peptide (AB); inmunoconjugado comprising Said Antibody; method to Treat or prevent Alzheimer's disease purchaseOf the above Antibody, kit comprising the Antibody.

Isolated Antibody that binds to beta Amyloid Peptide Derivative of cyclic Peptide (AB); inmunoconjugado comprising Said Antibody; method to Treat or prevent Alzheimer's disease purchaseOf the above Antibody, kit comprising the Antibody.

机译:与环状肽的β淀粉样肽衍生物结合的分离抗体;包含所述抗体的免疫缀合物;购买或治疗上述阿尔茨海默氏病的方法,包括该抗体的试剂盒。

摘要

An isolated antibody that specifically binds to a cyclic peptide comprising the conformational epitope which has at least the amino acid sequences GSNK or SNKG, wherein the K (lysine) is solvent-exposed and wherein the antibody can specifically bind to amyloid beta is described. Methods of treating and preventing Alzheimer's disease, as well as methods to produce the antibody, are also described.
机译:描述了一种分离的抗体,其与包含至少具有氨基酸序列GSNK或SNKG的构象表位的环状肽特异性结合,其中K(赖氨酸)被溶剂暴露,并且其中所述抗体可以与淀粉状蛋白β特异性结合。还描述了治疗和预防阿尔茨海默氏病的方法以及产生抗体的方法。

著录项

  • 公开/公告号CL2012002438A1

    专利类型

  • 公开/公告日2013-09-13

    原文格式PDF

  • 申请/专利权人 THE UNIVERSITY OF BRITISH COLUMBIA;

    申请/专利号CL20120002438

  • 发明设计人 CASHMAN NEIL R;

    申请日2012-09-03

  • 分类号A61K39/395;C07K14/47;C12N15/13;G01N33/53;

  • 国家 CL

  • 入库时间 2022-08-21 16:42:11

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