NEW MAITANINOIDS AND APPLICATION OF MENTATED MAITANINOIDS TO OBTAIN ANTIBODY CONJUGATES

摘要

The present invention relates to a compound of formula (I) in which ALK is a (C-C) alkylene group; each X and X independently represent one of the following groups: -CH = CH-, -CO-, -CONR-, - NRCO-, -COO-, -OCO-, -OCONR-, -NRCOO-, -NRCONR'-, - NR-, -S (O) (n = 0, 1 or 2) or -O-; R and R ′ are independently H or a (C -C) alkyl group; i is an integer from 1 to 40, preferably from 1 to 20, and more preferably from 1 to 10; j is an integer equal to 1 when X represents -CH = CH-, and 2 when X is -CH = CH-; Z represents a simple bond, -O- or -NH-, and R 5 represents H or (C-C) alkyl, (C-C) cycloalkyl, aryl, heteroaryl or (C-C) heterocycloalkyl group; or Z represents a simple bond and R represents a halogen. The invention relates to the use of the mentioned maytansinoid to obtain conjugates with antibody having affinity for tumor cells.