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POLYPEPTIDE COMPRISING Nef, p17 Gag, p24 Gag and RT CAPABLE OF RAISING AN IMMUNE RESPONSE AGAINST THE NATIVE HIV ANTIGEN
POLYPEPTIDE COMPRISING Nef, p17 Gag, p24 Gag and RT CAPABLE OF RAISING AN IMMUNE RESPONSE AGAINST THE NATIVE HIV ANTIGEN
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机译:包含Nef,p17 Gag,p24 Gag和RT的多肽,可引发针对天然HIV抗原的免疫反应
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摘要
This invention relates to HIV polypeptide and polynucleotide fusions of Gag, Pol and Nef which are useful in immunogenic compositions and vaccines. The invention relates in particular to a polypeptide which comprises Nef or an immunogenic fragment thereof, and p17 Gag and/or p24 Gag or immunogenic fragments thereof, wherein when both p17 and p24 Gag are present there is at least one HIV antigen or immunogenic fragment between them. The polypeptide may also comprise Pol or RT or an immunogenic fragment thereof.
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