ISOLATED TRUNCATED MAMMALIAN URICASE COMPRISING AN AMINO ACID SUBSTITUTION AT POSITION 46, THE SAID TRUNCATION AND AMINO ACID SUBSTITUTION BEING RELATIVE TO A NATURALLY OCCURRING PIG URICASE

摘要

The present invention relates to genetically modified proteins with uricolytic activity. More specifically, the invention relates to proteins comprising truncated oxidases and methods for producing them, including PEGylated proteins comprising truncated urate oxidases.