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Recombinant co-expression of vitamin k epoxide reductase subunit 1 to improve vitamin k dependent protein expression
Recombinant co-expression of vitamin k epoxide reductase subunit 1 to improve vitamin k dependent protein expression
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机译:重组共表达维生素K环氧还原酶亚基1以改善维生素K依赖性蛋白表达
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摘要
The present invention relates to a host organism containing recombinant nucleic acids coding for the vitamin K reductase complex subunit 1 (VKORC1) and recombinant nucleic acids coding for a vitamin K dependent (VKD) protein, wherein both the recombinant VKORC1 and the recombinant VKD protein are expressed in said host organism. Further, the present invention relates to a cell culture system comprising cells which contain said recombinant nucleic acids and to methods for improving the productivity of recombinant VKD protein expression in a host organism being cultured in suitable systems.
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