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Crystalline racemic ilaprazole hydrate, pharmaceutical compositions comprising it for inhibiting gastric acid secretion and use thereof in the preparation of medicaments for treating gastrointestinal inflammatory disorders
Crystalline racemic ilaprazole hydrate, pharmaceutical compositions comprising it for inhibiting gastric acid secretion and use thereof in the preparation of medicaments for treating gastrointestinal inflammatory disorders
The invention relates to crystalline forms of racemic ilaprazole, 2[[(4-methoxy-3-methyl-2-pyridinyl)-methyl]sulfinyl]-5-(1H-pyrrol-1-yl) 1H-Benzimidazole. The invention also relates to a pharmaceutical composition for inhibiting gastric acid secretion comprising a crystalline Form of ilaprazole according to the invention in an amount effective to inhibit gastric acid secretion and a pharmaceutically acceptable carrier. The invention also provides methods of treatment for various acid-related gastrointestinal (GI) disorders.
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