ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES OF A NON-ULCEROGENIC NOVEL SYNTHETIC MOLECULE: 2- (4,6-DIHYDROXY-2-MERCAPTOPYRIMIDIN-5-YL)-2-HYDROXY-1H-INDENE-1 3(2H)-DIONE (DMPI)

摘要

According to this invention, there is provided a novel easily synthesizable organic molecule 2-(4, 6-dihydroxy-2-mercaptopyriniidin-5-yl)-2-hydroxy-lH-indene-l, 3(2H)-Dione (DMPI), having molecular weight 310g/mol, meting point 360.43±2°C, UV spectra at 356.5, 260.5nm and a direct one step synthetic process thereof comprising, dissolving thiobarbiturin acid, 4.0 m moles in 10ml of 31.5 v/v acetic acid at 55 to 60°C, adding Ninydrine 4.0 m moles to the solution alongiwth 10 ml more acetic acid and 1 ml of concentrated sulphuric acid, stirring at 50-55°C for 3 hours till a black coloured solid product separates, filtering, washing with water and methanol followed by recrystallization in acetone.