NOVEL COUMARIN-CHALCONE HYBRIDS AS ANTICANCER AGENTS

摘要

The present invention relates to certain coumarin/chalcone compounds or a pharmaceutically acceptable salt thereof. The present invention particularly relates to the coumarin/chalcone compounds as anticancer agents useful for the treatment of cancer. The present invention also relates to the process of preparation of the said compounds. R may be selected from the group consisting of: H, CHO, COCH3, NHCOCH3, F, CI, Br, NO2, CF3, OCF3, CH3, C2H5, C3H7, Straight and branched alkyl chain up to six carbon, Straight and branched alkoxy/sulphoxy chain up to six carbon, phenyl or substituted phenyl ring, wherein the substituents in phenyl ring is selected from the group consisting of:(a) F, (b) CI, (c) Br, (d) NO2, (e) CF3, (f) CH3, (g) C2H5, (h) C3H7, (i) Straight and branched alkyl chain up to six carbon. X is selected from the group consisting of: 0, S, CH2, NR3, wherein R3 = H, CH3, C2H5, C3H7 R1 is selected from the group consisting of: H, CH3, C2H5, C3H7, Straight and branched alkyl chain up to eight carbons, cyclopentyl, cyclohexyl, piperidinyl, unsubstituted or substituted phenyl ring, wherein the substituents in phenyl ring is selected from the group consisting of (a) F, (b) CI, (c) Br, (d) NO2, (e) CF3, (f) CH3, (g) C2H5, (h) OCH3, (i) OC2H5, (j) 0CF3. R2 is selected from the group consisting of: CHO, -CH=CHCOR4 Wherein R4 is selected from the group consisting of: CH3, C2H5, C3H7, Straight and branched alkyl chain up to eight carbons, cyclopentyl, cyclohexyl, , aryl or heteroaryl or piperidinyl or thienyl or furyl or pyridyl or indolyl or phenyl, which may be unsubtituted or substituted by one, two or three substituent"s being independently selected from the group of consisting of :(a) F, CI, Br, NO2, CF3, CH3, C2H5, OCH3, OC2H5, CF3, NMe2, NEt2, SCH3, NHCOCH3.