A NOVEL TYPHOID VACCINE ELICITING MEMORY ANTIBODY RESPONSE FROM SINGLE DOSE IMMUNIZATION

摘要

The present investigation relates to entrapment of carbohydrate antigen such as Vi polysaccharide of Salmonella typhi in poly (DL) lactide (PDLLA) and polylactide-co-glycolide (PLGA) polymer particles. The formulated product not only elicits primary antibody titers from single dose application but also evokes memory antibody titer against the T independent antigen.