A NOVEL, ECONOMIC AND ECO - FRIENDLY PROCESS FOR BULK SYNTHESIS OF SINGLE PHASE TITANIUM DIOXIDE NANOPARTICLES AND ITS BIOCOMPATIBILITY EVALUATION

摘要

The present invention relates for bulk synthesis of single phase titanium dioxide nanoparticles using a novel, economic and eco-friendly process. The process helps in synthesis of single phase titanium dioxide particles having size of-12 nm comprising preparation of titanium halide solution using poly-ethylene glycol, adjusting the hydrogen ion concentration, aging, removal of halide ions followed by calcination and the single phase particles obtained thereby. The obtained single phase titanium dioxide particles were evaluated for biocompatibility and cyto-toxicity using Human T-lymphocytes and rutile phase particles are noticed to be biocompatible and do not cause any toxicity while anatase phase titanium particles showed toxicity. The claimed process is suitable for an industrial upscale for bulk production and allows the formation of single phase and stable titanium nano particles having the size of-12 nm.