首页> 外国专利> NOVEL STRATEGIES FOR IMPROVED CANCER VACCINES

NOVEL STRATEGIES FOR IMPROVED CANCER VACCINES

机译:改善癌症疫苗的新策略

摘要

Methods and compositions for forming anti-cancer vaccine complexes are disclosed The vaccine complex comprises an antibody moiety that binds to dendritic cells, such as an anti-CD74 antibody or antigen-binding fragment thereof, attached to an AD (anchoring domain) moiety and a xenoantigen, such as CD20, attached to a DDD (dimerization and docking domain) moiety, wherein two copies of the DDD moiety form a dimer that binds to the AD moiety, resulting in the formation of the vaccine complex The vaccine complex is capable of inducing an immune response against xenoantigen expressing cancer cells, such as CD13S sub neg CD20+ MM stem cells, and inducing apoptosis of and inhibiting the growth of or eliminating the cancer cells
机译:公开了用于形成抗癌疫苗复合物的方法和组合物。疫苗复合物包含与树突细胞结合的抗体部分,例如抗CD74抗体或其抗原结合片段,其附着于AD(锚定域)部分和附着于DDD(二聚体和对接域)部分的异种抗原(例如CD20),其中DDD部分的两个副本形成与AD部分结合的二聚体,从而形成疫苗复合物。疫苗复合物能够诱导对表达异种抗原的癌细胞(例如CD13S亚阴性CD20 + MM干细胞)的免疫应答,并诱导癌细胞凋亡,抑制癌细胞生长或消除癌细胞

著录项

  • 公开/公告号IN2011DN07776A

    专利类型

  • 公开/公告日2012-12-28

    原文格式PDF

  • 申请/专利权人

    申请/专利号IN7776/DELNP/2011

  • 发明设计人 GOLDENBERG DAVID M;CHANG CHIEN HSING;

    申请日2011-10-10

  • 分类号A61K51/00;

  • 国家 IN

  • 入库时间 2022-08-21 16:41:15

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