GENE EXPRESSION PROFILING FOR THE IDENTIFICATION, MONITORING, AND TREATMENT OF PROSTATE CANCER

摘要

Disclosed is a method for evaluating the presence of prostate cancer in a subject, the method comprising: determining a quantitative measure of an amount of secreted protein acidic and cysteine-rich (SPARC) in a sample obtained previously from the subject, wherein said sample comprises RNA; comparing the quantitative measure of SPARC in the sample to a reference value of SPARC; and determining that the subject has prostate cancer when the comparison at (b) indicates a higher quantitative measure of SPARC in the sample than the reference value of SPARC or determining that the subject does not have prostate cancer when the comparison at (b) indicates a lower or equivalent quantitative measure of SPARC in the sample than the reference value of SPARC, wherein an amount of SPARC in the sample positively correlates with an increased likelihood of the subject having prostate cancer.