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Methods for identifying a candidate inhibitor substance that inhibits hepsin activation of pro-urokinase type plasminogen activator
Methods for identifying a candidate inhibitor substance that inhibits hepsin activation of pro-urokinase type plasminogen activator
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机译:鉴定抑制尿激酶原型纤溶酶原激活剂的肝素激活的候选抑制剂物质的方法
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摘要
Disclosed is a method of identifying a candidate inhibitor substance that inhibits hepsin activation of pro-urokinase type plasminogen activator (pro-uPA), said method comprising: (a) Contacting a candidate substance with a first sample comprising hepsin and a pro-uPA substrate, and (b) Comparing amount of pro-uPA substrate activation in the sample with amount of pro-uPA substrate activation in a reference sample comprising similar amounts of hepsin and pro-uPA substrate as the first sample but that has not been contacted with said candidate substance, whereby a decrease in amount of pro-uPA substrate activation in the first sample compared to the reference sample indicates that the candidate substance is capable of inhibiting hepsin activation of single chain uPA (pro-uPA).
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