5- (3, 4-DICHLORO-PHENYL) -N- (2-HYDROXY-CYCLOHEXYL) -6- (2,2, 2-TRIFLUORO-ETHOXY) -NICO TINAMIDE AND SALTS THEREOF AS HDL CHOLESTEROL RAISING AGENTS

摘要

597514 Disclosed herein is a compound of formula I, specifically 5(-3,4-dichloro-phenyl)-N-2-hydroxy-cycloexyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide, preferably (1S, 2R)-I or (1R, 2R)-I. Additionally disclosed is a process for the manufacture thereof comprising coupling a halide intermediate with a boronic acid or boronic acid ester, in the presence of a palladium catalyst under basic conditions. Additionally disclosed is the use thereof in the treatment of diseases which can be treated with HDL-cholesterol raising agents.