METHODS AND COMPOSITION FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE BY PERFORMING ASSAYS TO DETECT METALLOPROTEINASE INHIBITOR 4 ON A BODY FLUID SAMPLE

摘要

Disclosed is an ex vivo method for evaluating renal status in a subject, comprising: performing one or more assays configured to detect Metalloproteinase inhibitor 4, in a body fluid sample obtained from the subject to provide an assay resu and correlating the assay result to the renal status of the subject by comparing a measured concentration of Metalloproteinase inhibitor 4 in said assay result to a threshold concentration of Metalloproteinase inhibitor 4 and: (i) assigning an increased likelihood of an event occurring when the measured concentration is above the threshold relative to a likelihood of the event occurring when the measured concentration is below the threshold, wherein the event is associated with reduced renal function; and/or (ii) assigning an increased likelihood of an event not occurring when the measured concentration is below the threshold relative to a likelihood of the event occurring when the measured concentration is above the threshold, wherein the event is associated with reduced renal function; and/or (iii) assigning an increased likelihood of an event occurring when the measured concentration is below the threshold relative to a likelihood of the event occurring when the measured concentration is above the threshold, wherein the event is an improved renal function.