A Pharmaceutical composition comprising at least water soluble Hydrophobic features a Therapeutically active substance and at least one selected from the sialoglicoesfingolipidos Compound, or a mixture of Glycosphingolipids Glycosphingolipids and sialoglicoesfingolipidos

摘要

Refers to a Pharmaceutical composition comprising: a) a Therapeutically active substance such as Hydrophobic doxorubicin, amphotericin B, among others, and (b) a compound selected from sialoglicoesfingolipidos shaped Micelles and a mixture of sialoglicoesfingolipidos and glicoesfing Olipidos as gangliosides, which form a complex with a Protein such as plasma Albumin.Also referred to a retrieval procedure that includes: a) solubilizing gangliosides in DISTILLED WATER or Saline At pH 3 - 7; (b) to add 10% ethanol or Dimethyl sulfoxide Solution containing the substance Therapeutically selected; (c) to incubate the mixture; (d) dialyse R The Micellar Solution compared to a solution of DISTILLED WATER or a pharmaceutically acceptable solutionAble to PH 3 - 7; (e) hatching GM1 Micelles formed by Complex - Therapeutically active substance in the presence of Human Serum Albumin; (f) the transparent aqueous solution and sterilized by Filtration sterilized Lyophilized Micelles; (g) and (H) resuspend the Lyophilized Micelles in a Pharmaceutically acceptable solution