首页> 外国专利> Water-soluble pharmaceutical composition comprising at least one therapeutically active substance having hydrophobic properties and at least one compound selected from among sialoglycosphingolipids, glycosphingolipids or a mixture of sialoglycosphingolipids and glycosphingolipids

Water-soluble pharmaceutical composition comprising at least one therapeutically active substance having hydrophobic properties and at least one compound selected from among sialoglycosphingolipids, glycosphingolipids or a mixture of sialoglycosphingolipids and glycosphingolipids

机译:水溶性药物组合物,其包含至少一种具有疏水性质的治疗活性物质和至少一种选自唾液酸糖鞘脂,糖鞘脂或唾液酸糖鞘脂和糖鞘脂的混合物的化合物

摘要

The invention relates to water-soluble pharmaceutical compositions comprising at least one therapeutically active substance and at least one compound selected from among sialoglycosphingolipids, glycosphingolipids or a mixture of sialoglycosphingolipids and glycosphingolipids, in which at least one of the therapeutically active substances is a drug with hydrophobic characteristics. In particular, the invention relates to injectable sterile compositions formed by nanomicelles of glycosphingolipids or modified glycosphingolipids, which can be non-covalently coated with albumin and which allow the delivery and controlled release of highly hydrophobic molecules.
机译:本发明涉及水溶性药物组合物,其包含至少一种治疗活性物质和至少一种选自唾液酸糖鞘脂,糖鞘脂或唾液酸糖鞘脂与糖鞘脂的混合物的化合物,其中至少一种治疗活性物质是具有疏水性的药物特征。特别地,本发明涉及由糖鞘脂或修饰的糖鞘脂的纳米胶束形成的可注射无菌组合物,其可以非共价地用白蛋白包被并且允许递送和控制释放高疏水性分子。

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