首页> 外国专利> ARYL AND HETEROARYL UREA CHK1 INHIBITORS FOR USE AS RADIOSENSITIZERS AND CHAMOSENSITIZERS

ARYL AND HETEROARYL UREA CHK1 INHIBITORS FOR USE AS RADIOSENSITIZERS AND CHAMOSENSITIZERS

机译：芳基和杂基尿素CHK1抑制剂，用作放射性敏化剂和致敏剂

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摘要

Aryl- and heteroaryl-substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.

机译：公开了可用于治疗与DNA复制中的DNA损伤或损伤有关的疾病和状况的芳基和杂芳基取代的脲化合物。还公开了制备化合物的方法及其作为治疗剂的用途，例如，用于治疗以DNA复制，染色体分离或细胞分裂缺陷为特征的癌症和其他疾病。

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公开/公告号PL212707B1

专利类型
公开/公告日2012-11-30

原文格式PDF
申请/专利权人 ICOS CORPORATION;
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申请/专利号PL20020364564
发明设计人 KEEGAN KATHLEEN S.;KESICKI EDWARD A.;GAUDINO JOHN JOSEPH;COOK ADAM WADE;COWEN SCOTT DOUGLAS;BURGESS LAURENCE EDWARD;
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申请日2002-03-01
分类号C07D241/20;A61K31/4965;A61K31/497;A61K31/498;A61K31/5377;A61K45/06;A61P35;A61P43;C07D213/30;C07D213/40;C07D213/75;C07D213/77;C07D215/34;C07D231/40;C07D239/42;C07D239/46;C07D241/12;C07D241/30;C07D241/44;C07D241/54;C07D251/22;C07D253/06;C07D253/07;C07D257/06;C07D277/48;C07D401/12;C07D401/14;C07D403/06;C07D403/12;C07D405/12;C07D409/12;C07D409/14;C07D453/02;C07D521;
国家 PL
入库时间 2022-08-21 16:40:21

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