ISOLATED ANTIBODY THAT BINDS SPECIFICALLY TO HUMAN P-SELECTIN GLYCOPROTEIN LIGAND 1

摘要

The invention relates to an isolated antibody that binds specifically to human P-Selectin Glycoprotein Ligand 1 (PSGL-1) without interfering with binding between PSGL-1 and P-Selectin, wherein the antibody, upon binding to human PSGL-1 expressed on an activated T cell, induces death of the activated T cell. The invention further relates to an isolated nucleic acid, a vector, host cell, pharmaceutical composition and to use of effective amount of an antibody for the preparation of medicinal agent for modulating a T cell-mediated immune response in a subject.