amelreuma food supplement, useful for elasticity, the restoration and the lubrication of the cartilages, ch and contributes to the normal mobility of the joints.

• 1. 用于稳定承重关节、改善承重关节的活动性和控制承重关节的软骨基质退变的设备和方法 [P] . 中国专利： CN103945897B . 2016.03.16
• 2. 用于稳定承重关节、改善承重关节的活动性和控制承重关节的软骨基质退变的设备和方法 [P] . 中国专利： CN103945897A . 2014-07-23
• 3. Herbal remedy / food supplement from willow bark u. The rose hip peel for the treatment and prophylaxis of healthy joints / cartilage and their mobility. Antiphlogistikum [P] . 德国专利： DE102013021979A1 . 2014-07-03

  机译： 柳树皮u的草药/食品补充剂。玫瑰果皮用于治疗和预防健康的关节/软骨及其活动性。消炎药

• 4. Herbal remedy / food supplement from willow bark and rose hip peel for the treatment and prophylaxis of healthy joints / cartilage and their mobility / anti-inflammatory properties [P] . 德国专利： DE202012012459U1 . 2013-06-06

  机译： 柳树皮和玫瑰果皮的草药/食品补充剂，用于治疗和预防健康的关节/软骨及其活动性/抗炎特性

• 5. Food supplement containing a cartilage supplement [P] . 美国专利： US6391864B1 . 2002-05-21

  机译： 含软骨补充剂的食物补充剂

• 1. Economic growth and nutrition transition： an empirical analysis comparing demand elasticities for foods in China and Russia [J] . Christine Burggraf2, Lena Kuhn2, ZHAO Qi-ran12, 农业科学学报：英文版 . 2015,第006期
• 2. Economic growth and nutrition transition:an empirical analysis comparing demand elasticities for foods in China and Russia [J] . Christine Burggraf, Lena Kuhn, ZHAO Qi-ran, 农业科学学报（英文版） . 2015,第006期
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• 4. Nitrite and nitrotyrosine concentrations in articular cartilage, subchondral bone, and trabecular bone of normal juvenile, normal adult, and osteoarthritic adult equine metacarpophalangeal joints. [J] . van der Harst M, Bull S, Brama PA, The Journal of rheumatology . 2006,第8期
• 5. Role of uppermost superficial surface layer of articular cartilage in the lubrication mechanism of joints. [J] . Kumar P, Oka M, Toguchida J, Journal of Anatomy . 2001,第Pta3期
• 6. Investigating an Approach to Identifying the Biomechanical Differences between Intercostal Cartilage in Subjects with Pectus Excavatum and Normals in vivo: Preliminary Assessment of Normal Subjects [C] . Krzysztof Rechowicz, Frederic McKenzie, Zhenzhen Yan, SPIE Conference on Medical Imaging . 2009
• 7. The use of supplemental foods by participants in the Special Supplemental Food Program for Women, Infants and Children (WIC) and the Commodity Supplemental Food Program (CSFP). [D] . Keys, Marilyn C. 1994
• 8. Cartilage proteoglycans from normal and osteochondrotic porcine joints. [O] . T Nakano, J R Thompson, F X Aherne 1985
• 9. Lubrication of animal joints. iii. the effect of certain chemical alterations of the cartilage and lubricant [O] . Frank C. Linn, Eric L. Radin 1968

• 1. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004） （P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期
• 2. MRI Characteristics and Transverse Relaxation Time Measurements in Normal Growing Cartilage [J] . 李小明 ,王仁发 ,李勇刚 . 华中科技大学学报（医学）（英德文版） . 2004,第004期
• 3. Restoration of arterial baroreflex function contributes to organ protection in spontaneously hypertensive rats treated with long- term hydrochlorothiazide mixture [J] . LUZe-An XIEHe-Hui XULi-Ping YINAn-Fan MIAOChao-Yu SUDing-Feng . 第二军医大学学报 . 2004,第2期
• 4. 组织工程软骨及膝关节被动活动仪修复羊膝关节负重区软骨的实验研究 [C] . 郭全义 ,杜国跃 ,孙明学 . 中国残疾人健康协会2005年国际康复论坛暨第六次全国康复医学工程与康复工程学术研讨会 . 2005
• 5. 合并有盘状半月板的膝关节骨关节炎中内侧胫骨平台软骨损伤情况的观察 [A] . 赵哲 . 2018