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Process for the treatment of neoplasia with a combination of chemotherapeutic agents and radiation
Process for the treatment of neoplasia with a combination of chemotherapeutic agents and radiation
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机译:结合化学治疗剂和放射线治疗肿瘤的方法
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摘要
Compound of Formula (I) for administration in combination with ionizing radiation for utilizaciónen treating growth tumoralen the Quex and Y are identical or different and are hydrogen, halogen, OR3, SR3, 10 NR3R4 or NHacyl; Z is a halogen or CF3; where R3 and R4 the same or different and being hydrogen, lower alkyl of 1 to 7 carbon atoms, uncompuesto aralkyl selected from the group consisting of benzyl, benzhydryl or methoxybenzyl, or uncompuesto aryl selected from the group consisting of phenyl, chlorophenyl, tolyl, methoxyphenyl and naphthyl; being NHacyl alkanoyl or amide aroyl, being the alkanoyl an alkyl radical carbonyl wherein alkyl is unradical hydrocarbon straight chain or branched saturated or unsaturated having from 1 to 20 decarbono atoms ; and R1 and R2 are identical or different and are hydrogen, acyl or aroyl, acyl being an alkanoyl group of 1 to 20 carbon átomosde and aroyl being benzoyl or naphthoyl; and salts or solvates thereof.
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机译:与电离辐射联合施用的式(I)化合物用于治疗生长瘤的Quex和Y相同或不同,并且为氢,卤素,OR 3,SR 3,10 NR 3 R 4或NH酰基; Z为卤素或CF 3;其中R3和R4相同或不同并且为氢,1至7个碳原子的低级烷基,选自由苄基,二苯甲基或甲氧基苄基组成的组中的不完全芳烷基,或选自由苯基,氯苯基,甲苯基中的不完全芳基,甲氧基苯基和萘基;为NH酰基链烷酰基或酰胺芳酰基,为链烷酰基为烷基的羰基,其中烷基为具有1至20个脱碳原子的非自由基烃直链或支链饱和或不饱和的烷基; R 1和R 2相同或不同,且为氢,酰基或芳酰基,酰基为1至20个碳原子的烷酰基的烷酰基,而芳酰基为苯甲酰基或萘甲酰基;及其盐或溶剂化物。
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