heterocyclic compounds that bind to chemokine receptors and exhibit improved efficacy

摘要

A compound selected from the group consisting of: 4- (3,3 "-dimethyl-3 ', 4', 5 ', 6'-tetrahydro-2'H-cis- [2,2'; 6 ', 2" ] terpyridin-1'-yl) -butylamine; [3-aminomethyl-4-meso- (3,3 "-dimethyl-3 ', 4', 5 ', 6'-tetrahydro-2'H-cis- [2,2'; 6 ', 2"] terpyridine -1'-ylmethyl) -phenyl] -methanol; 4- (3,3 "-diisopropyl-3 ', 4', 5 ', 6'-tetrahydro-2'H-cis- [2,2'; 6 ', 2"] terpyridine-1'-yl) - butylamine; (2'R, 6'S) -1 '- [3- (1H-imidazol-4-yl) -propyl] -3,3' -dimethyl-1 ', 2', 3 ', 4', 5 ', 6 'hexahydro-cis- [2,2'; 6 ', 2 "] terpyridine; (2'R, 6'S) -3,3 '-dimethyl-1' - [2- (1H-pyrazol-4-yl) -ethyl] -1 ', 2', 3 ', 4', 5 ', 6 '-hexahidro- [2,2'; 6 ', 2 "] terpyridine; [2-meso- (3,3 "-dimethyl-3 ', 4', 5 ', 6'-tetrahydro-2'H-cis- [2,2'; 6 ', 2"] terpyridine-1' ylmethyl) -5-hydroxymethyl-benzyl] -urea; 2-meso- (3,3 "-dimethyl-3 ', 4', 5 ', 6'-tetrahydro-2'H-cis- [2,2'; 6 ', 2"] terpyridin-1'-ylmethyl ) -5-hydroxymethyl-benzamide; 4- (3,3 "-dimethyl-3 ', 4', 5 ', 6'-tetrahydro-2'H-cis- [2,2'; 6 ', 2"] terpyridin-1'-ylmethyl) - 3-hydroxymethyl-benzamide; 4- (3,3 "-dimethyl-3 ', 4', 5 ', 6'-tetrahydro-2'H-cis- [2,2'; 6 ', 2"] terpyridin-1'-ylmethyl) -3-hydroxymethyl-benzoic acid; N- [4- (3,3 "-dimethyl-3 ', 4', 5 ', 6'-tetrahydro-2'H-cis- [2,2'; 6 ', 2 "] terpyridin-1'-ylmethyl) -3-hydroxymethyl-benzyl] -methanesulfonamide; acid methyl ester [4- (3,3 "-dimethyl-3 ', 4', 5 ', 6'-tetrahydro-2'H-cis- [2,2'; 6 ', 2"] terpyridine-1 'ylmethyl) -3-hidroximetilbencilamino] - acetic acid; N- [4- (3,3 "-dimethyl-3 ', 4', 5 ', 6'-tetrahydro-2'H-cis- [2,2'; 6 ', 2"] terpyridine-1' ylmethyl) -3-hydroxymethyl-benzyl] -2,2-dimethyl- propionamide.