Use of conjugates of hyaluronic acid in the local treatment of hyperproliferative skin diseases

摘要

Use of a conjugate between hyaluronic acid or a derivative thereof, and seleccionadosde antitumor drugs paclitaxel or 5-fluorouracil, wherein the hyaluronic acid derivative is selected from salts with basesorgánicas and / or inorganic, hyaluronic acid esters with alcohols of the aliphatic, araliphatic, cycloaliphatic, aromatic, cyclic and heterocyclic amides of hyaluronic acid with amines of the aliphatic, araliphatic, cycloaliphatic, aromatic, cyclic and heterocyclic derivatives O-sulfated, inner esters of hyaluronic acid with unporcentaje esterification not more than 20%, deacetylated hyaluronic acid, hyaluronic acid obtained by percarboxylates the oxidation of primary hydroxyl groups of the N-acetylglucosamine with gradode percarboxylation ranging from 0.1 to 100%, for the preparation of a pharmaceutical composition for eltratamiento topic of actinic keratosis.