Immunization against serogroup meningococcus and proteins using

摘要

A composition comprising one or more immunogenic polypeptides from Neisseria meningitidis serogroup B to use in a method of immunizing a subject against infection by serogroup Y of Neisseria meningitidis, wherein the polypeptides include 1, 2, or 3: (i) NadA protein which (a) has 80% or more identity to SEQ ID NO: 2 or (b) comprises a fragment of at least 20 consecutive amino acids of SEQ ID NO: 1, wherein the fragment comprises an epitope; (Ii) a protein "741", which (a) has 80% or more identity to SEQ ID NO: 3 or (b) comprises a fragment of at least 20 consecutive amino acids of SEQ ID NO: 3, wherein the fragment comprises an epitope ; and / or (iii) a protein "287", which (a) has 80% or more identity to SEQ ID NO: 6 or (b) comprises a fragment of at least 20 consecutive amino acids of SEQ ID NO: 6 wherein the fragment it comprises an epitope;