6-1H-imidazo derivatives-quinazoline and quinolines, new MAO inhibitors and receptor ligands imidazoline

摘要

Compounds of formula (I), their salts and / or pharmaceutically acceptable solvates and corresponding pharmaceutical formulations, for use in the pharmacological treatment of depression including major depressive disorder, dysthymic disorder, bipolar II disorder, manic depression, anxiety disorders and panic disorder: wherein: - X is independently selected from -CH group or a nitrogen atom (-N); - W is independently selected from an aryl group, or a heteroaryl group of formula II: - when W is an aryl group, is an unsubstituted or substituted phenyl, with one or more substituents independently selected from halogen (-F, -Cl, -Br), trifluoromethyl (-CF3), alkyl (-R2), hydroxyl (OH), alkoxy (-OR2), trifluoromethoxy (-OCF3), cyano (-CN), carboxamido (-CONHR3 or -NHCOR3 or CONR2R3 or - NR2COR3), carbonyl (-CO-R3), alkylthio or thiol (-SR3), sulfinyl (-SOR 3) and sulfonyl (-SO2R3) being R2 and R3 as defined below; - when W is an heteroaryl group of formula II, it is a 5- or 6 benzofused members, in which: - Z and Y are independently selected from: an oxygen atom (-O-), a sulfur atom (- S-) or the groups: -CHR3-, -CR3 =, -NH-, -N =; - Q is independently selected from the groups: -CHR3-, CH =, -CR 3 =, -CHR3-CH2-; provided that the combination of groups Y, Z, Q leads to: 1,3-benzodioxole, benzofuran, 2,3-dihydrobenzofuran, benzothiophene, 2,3-dihydrobenzothiophene, indole, 2,3-dihydroindol, benzimidazole, benzoxazole, benzothiazole , 2H-3,4-dihydrobenzopyran, [1,4] -benzodioxine, 2,3-dihydro- [1,4] -benzodioxine (1,4-benzodioxan); - R1 is independently selected from hydrogen (-H) or C1-C4 alkyl or hydroxymethyl (-CH2OH), aminomethyl (-CH2NH2), alkylaminomethyl [-CH2NH (R2)], dialkylaminomethyl [-CH2N (R2) 2], trifluoromethyl ( CF3); alkyl group is a C1-C4 hydrocarbon chain C1-C4 saturated or unsaturated, straight or branched; provided that in compounds of formula (I) not more than two R1 groups substituting the imidazole ring, are simultaneously C1-C4 alkyl or trifluoromethyl (-CF3) and only one R1 group is hydroxymethyl (CH2OH), aminomethyl (-CH2NH2) , alkylaminomethyl [-CH2NH (R2)], dialkylaminomethyl [-CH2N (R2) 2]; - R2 is an alkyl chain C1-C6 alkyl; herein C1-C6 alkyl chain is defined as above but C1-C4 optionally substituted with an aryl, aryl being herein as defined above; - R3 is independently selected from hydrogen, C1-C4 alkyl as defined above for R1; including all possible tautomers of the compounds of formula (I).