Synthesis of a PEG moiety-6 from commercial chemicals low cost

摘要

A process for preparing a linker of fórmuUn process for preparing a linker of formula (A), comprising the following reactions: * (A), comprising the following reactions: ** ** Formula wherein R represents one of the * ** nEXT Formula wherein R represents one of the following structures ** ** Formula and in which PG pueientes structures ** ** Formula and wherein PG can be any form carbamate ** ** of Formula carbamate be any shape ** ** Formula wherein R1 is alkyl or aryl and proferentem wherein R1 is alkyl or aryl and more preferably R1 = 9-fluorenylmethyl where PG is 9-fluorenente R1 = 9- fluorenylmethyl where PG is 9-fluorenilmetoxicarboniloy more preferably R1 = tert-bilmetoxicarboniloy more preferably R1 = tert-butyl is where PG Boc, t-butoxycarbonyl (-COOCH (PG is Boc Cutilo where, t-butoxycarbonyl (-COOCH (CH3) ) or where PG represents ** ** Formula wherein R2H3)) or where PG represents ** Formula * * Wherein R 2 = alkyl or aryl and more preferably R2 = H = alkyl or aryl and more preferably R2 = H where PG is formyl or R2 is methyl which PG esadonde PG is formyl or R2 is methyl which PG esacetilo and more preferably where R2 = phenyl docetilo and more preferably where R2 = phenyl wherein PG is benzoyl or further wherein PG puedende PG is benzoyl or further wherein PG can be alkyl or aryl and more preferably allyl or be alkyl or aryl and more preferably allyl or more preferably benciloy n represents 1-19. more preferably benciloy n represents 1-19.