COMBINATION PRODUCT COMPRISING AN ANTAGONIST OR INVERSE AGONIST OF HISTAMINE RECEPTOR HSB3 /SBAND AN ANTIPSYCHOTIC OR ANTIDEPRESSANT AGENT, AND USE THEREOF FOR THE PREPARATIONOF A MEDICAMENT THAT PREVENTS THE ADVERSE EFFECTS OF PSYCHOTROPIC DRUGS

摘要

A medicament comprising, in a pharmaceutically acceptable vehicle, an anti-psychotic or an antidepressant (A), having only an adverse effect of body weight gain or sedation and an antagonist and / or inverse agonist (B) of the H3 receptor of the histamine, said histamine H3 receptor antagonist and / or inverse agonist being present in a therapeutically effective amount to achieve at least one of the following three effects: suppressing or at least limiting the undesirable effect of weight gain, suppression or limitation of the adverse effect on alertness, epilepsy / seizures, increased pro-cognitive effect of treatment. Use of such an antagonist or inverse agonist for the preparation of a medicament for providing at least one of said three effects in a patient treated with such an antipsychotic or antidepressant.