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PHARMACEUTICAL COMPOSITIONS COMPRISING PH-SENSITIVE BLOCK COPOLYMERS AND A HYDROPHOBIC DRUG
PHARMACEUTICAL COMPOSITIONS COMPRISING PH-SENSITIVE BLOCK COPOLYMERS AND A HYDROPHOBIC DRUG
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机译:包含PH敏感嵌段共聚物和疏水性药物的药物组合物
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摘要
The present invention relates to a pharmaceutical composition of abiologically active agent and a block copolymer composed of a poly(ethyleneoxide) forming hydrophilic segment and a poly(butyl (alkyl)acrylate-co-(alkyl)acrylic acid) that is capable of forming supramolecular assemblies ormicelles under favourable conditions. The supramolecular assemblies ormicelles formed from said polymers associate or dissociate reversibly uponchanges in the environmental pH. The pharmaceutical compositions of thepresent invention contain hydrophobic drugs, cations or polycationiccompounds, which can be delivered to the body by oral route or other routes ofadministration.
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