USE OF GLUTAMYL CYCLASE INHIBITORS IN THE TREATMENT OF FAMILIAL BRITISH DEMENTIA AND FAMILIAL DANISH DEMENTIA

摘要

The present invention provides novel physiological substrates ofmammalian glutaminyl cyclase (QC, EC 2.3.2.5), new effectors of QC andthe use of such effectors and pharmaceutical compositions comprisingsuch effectors for the treatment of diseases that can be treated bymodulation of QC-activity, e.g. diseases selected from the groupconsisting of duodenal cancer with or w/o Helicobacter pylori infections,colorectal cancer, Zolliger-Ellison syndrome, Familial British Dementia andFamilial Danish Dementia.(see formula 1)