An enantioselective synthesis of pyrrolidine-substituted flavones

摘要

The present invention relates to an enantioselective synthesis of (+)-enantiomer of pyrrolidines substituted with flavones, represented by Formula1 or salts thereof, which are inhibitors of cyclin dependant kinases and can beused for treatment of proliferative disorders such as cancer. wherein Ar hasthe meaning as indicated in the claims.