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Combinations of gene deletions for live attenuated shigella vaccine strains

机译：减毒活志贺氏菌疫苗株基因缺失的组合

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摘要

Shigella vaccine strains whose primary attenuating feature is deletion of thevirG(icsA) gene and additional two or more deletions in setAB(shET1), senA(shET2),senB(shET2- 2), stxAB, and msbB2 genes. Thus, the vaccine strain will have threeor more deletions in the identified genes, will be safer, and will reduce or eliminatesymptoms of fever and diarrhea in humans. The following specific vaccine strainshave been constructed: WRSS3 (ΔsenA, ΔsenB, ΔvirG, ΔmsbB2),WRSf2G15 (ΔvirG, ΔsetAB, ΔsenA, ΔsenB, ΔmsbB2),and WRSd5 (ΔvirG, Δ stxAB, ΔsenA, ΔsenB, ΔmsbB2).

机译：志贺氏菌疫苗株，其主要减毒功能是缺失virG（icsA）基因以及setAB（shET1），senA（shET2），senB（shET2- 2），stxAB和msbB2基因。因此，疫苗株将具有三个或已鉴定基因中的更多缺失，将更安全，并将减少或消除人类发烧和腹泻的症状。以下特定疫苗株已构建：WRSS3（ΔsenA，ΔsenB，ΔvirG，ΔmsbB2），WRSf2G15（ΔvirG，ΔsetAB，ΔsenA，ΔsenB，ΔmsbB2），和WRSd5（ΔvirG，ΔstxAB，ΔsenA，ΔsenB，ΔmsbB2）。

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公开/公告号AU2008246150B2

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公开/公告日2013-07-25

原文格式PDF
申请/专利权人 THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY WALTER REED ARMY INSTITUTE OF RESEARCH;
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申请/专利号AU20080246150
发明设计人 BARNOY SHOSHANA;VENKATESAN MALABI M.;RANALLO RYAN T.;
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申请日2008-04-25
分类号A61K39/02;
国家 AU
入库时间 2022-08-21 16:37:22

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