A METHOD FOR INCREASING ANTIBODY-DEPENDENT CYTOTOXICITY WITH CASTANOSPERMINE

摘要

A composition comprising recombinant immunoglycoproteins, wherein the recombinant immunoglycoprotein molecules each comprise a binding domain that specifically binds to CD37 and have at least a 5-fold increase in antibody-dependent cellular cytotoxicity (ADCC) as compared to control immunoglycoproteins of the same encoded amino acid sequence produced in Chinese Hamster Ovary (CHO) cells, and wherein at least 60% of the recombinant immunoglycoprotein molecules are non-fucosylated.