MARKER FOR DIAGNOSING LIVER CANCER CONTAINING ANTI-ATIC AUTOANTIBODY, AND COMPOSITION FOR DIAGNOSING LIVER CANCER CONTAINING ANTIGEN THEREOF

摘要

The present invention relates to a fragment comprising an autoantibody which specifically binds to ATIC or an antigen-binding site (i.e. paratope) of the autoantibody, a composition for diagnosing liver cancer containing an agent which measures the expression level of the fragment, a hybridoma cell line producing the autoantibody, a diagnostic kit for liver cancer containing the composition, a method for diagnosing liver using the composition, and a method for screening a liver cancer therapeutic agent using the autoantibody. Using the anti-ATIC specific autoantibody of the present invention as a marker for diagnosing liver cancer, the occurrence of liver cancer can be diagnosed using a non-invasive biological sample such as blood, plasma, serum, lymph tissue, and the like, with a sensitivity of about 87% and a specificity of about 88%, and as liver cancer can be easily diagnosed using an amino acid sequence identified in the present invention, the autoantibody is effective for developing a diagnostic kit for liver cancer.