COMBINATIONS OF ANTI -HCV - ENTRY FACTOR ANTIBODIES, PROTEIN KINASE INHIBITORS OR ALISPORIVIR FOR THE TREATMENT AND THE PREVENTION OF HCV INFECTION

摘要

The present invention provides combinations for use in the treatment or the prevention of HCV infection. In particular, combinations are provided that comprise two host-targeting agents, such as for example at least one anti-HCV-entryfactor antibody and at least one protein kinase inhibitor, or at least one anti-HCV-entry factor antibody and alisporivir, or at least one protein kinase inhibitor and alisporivir, wherein the two host-targeting agents act in a highly synergistic manner to inhibit HCV entry and infection in susceptible cells. Also provided are pharmaceutical compositions and kits comprising such combinations and methods of using these compositions and kits for treating or preventing HCV infection.