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SELF-EXPANDABLE BIODEGRADABLE STENT MADE OF CLAD RADIOPAQUE FIBERS COVERED WITH BIODEGRADABLE ELASTIC FOIL AND THERAPEUTIC AGENT AND METHOD OF PREPARATION THEREOF
SELF-EXPANDABLE BIODEGRADABLE STENT MADE OF CLAD RADIOPAQUE FIBERS COVERED WITH BIODEGRADABLE ELASTIC FOIL AND THERAPEUTIC AGENT AND METHOD OF PREPARATION THEREOF
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机译:包覆有生物可降解弹性箔和治疗剂的复合不透辐射纤维的自扩张生物可降解支架及其制备方法
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摘要
Self-expanding biodegradable stent comprising a base structure consisting of interlaced biodegradable fibres, characterized in that the core polymeric fibre containing an x-ray opaque filler is covered with an additional polymer, or the polymeric core fibre is provided with a uniformly dispersed x-ray opaque matter, or the polymeric core fibre is coated with a polymer in which an x-ray opaque matter is uniformly dispersed, the interlaced fibres forming the complete basic structure of the stent being also coated with a dispersion of a an x-ray opaque filler and with a polymer, said coatings forming a biodegradable foil provided on the basic structure of the stent and encapsulating an active substance, said active substance being selected from the group of substances including medicaments; proteins, enzymes/genes; stem cells or radioactive substances used for the Ideal treatment of tumors. 2. Method of manufacturing a self-expanding biodegradable stent having a base structure consisting of interlaced biodegradable fibres, characterized sn that it comprises the steps of covering the core polymeric fibre containing an x-ray opaque filler with an additional polymer, or providing the polymeric core fibre with a uniformly dispersed x-ray opaque matter, or coating the polymeric core fibre with a polymer in which an x-ray opaque matter is uniformly dispersed, followed by the step of coating the interlaced fibres forming the complete basic structure of the stent with a dispersion of a an x-ray opaque filler and with a polymer in order to provide a biodegradable foil on the basic structure of the stent, in which foil an active substance is encapsulated, in which step the stent provided with an x-ray opaque filler undergoes heat treatment and then it is coated with a biodegradable elastic foil made of x-ray opaque fibres containing a first medicament and after having been prepared in this manner the stent is subjected to heat treatment for the second time and recoated with a further, thinner biodegradable foil containing a second, different medicament.
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