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LIPIDS CAPABLE OF CONFORMATIONAL CHANGE AND THEIR USE IN FORMULATIONS TO DELIVER THERAPEUTIC AGENTS TO CELLS

机译：能够进行构象变化的脂质及其在配方中用于将治疗剂递送至细胞的用途

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摘要

The invention provides lipid-based composition for use in the administration of therapeutic payloads to target cells or tissues in vivo. The lipid compounds of the invention include a peptide-based moiety which is induced to change its conformation upon entering a cell or intracellular compartment. The induced conformation change in the peptide-based moiety consequently triggers the efficient release of the payload from the lipid-based composition.

机译：本发明提供了基于脂质的组合物，用于在体内向靶细胞或组织施用治疗有效载荷。本发明的脂质化合物包括基于肽的部分，其在进入细胞或细胞内区室时被诱导改变其构象。因此，基于肽的部分中诱导的构象变化触发了有效负载从基于脂质的组合物中的有效释放。 展开▼

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公开/公告号WO2013032643A2

专利类型

公开/公告日2013-03-07

原文格式PDF

申请/专利权人 DICERNA PHARMACEUTICALS INC.;BASU SUJIT KUMAR;
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申请/专利号WO2012US49822

发明设计人 BASU SUJIT KUMAR;
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申请日2012-08-07

分类号A61K39/395;A61K48;A61K31/685;A61K47/48;A61K47/30;A61K9/127;

国家 WO

入库时间 2022-08-21 16:34:29

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1. 包含固醇修饰的脂质和纯化的分枝杆菌脂质细胞壁组分的脂质体组合物及其在肺结核诊断中的用途 [P] . 中国专利： CN104685358B . 2017.09.22

2. 包含固醇修饰的脂质和纯化的分枝杆菌脂质细胞壁组分的脂质体组合物及其在肺结核诊断中的用途 [P] . 中国专利： CN104685358A . 2015-06-03

3. LIPIDS CAPABLE OF CONFORMATIONAL CHANGE AND THEIR USE IN FORMULATIONS TO DELIVER THERAPEUTIC AGENTS TO CELLS [P] . 世界知识产权组织专利： WO2013032643A3 . 2013-04-25

机译：能够进行构象变化的脂质及其在配方中用于将治疗剂递送至细胞的用途

4. Cationic lipid, lipid formulations comprising same and use thereof in the preparation of therapeutic agents for delivering to cells [P] . IL244945A . 2020-06-30

机译：阳离子脂质，包含该脂质的脂质制剂及其在制备用于递送至细胞的治疗剂中的用途

5. Cationic lipid, lipid formulations comprising same and use thereof in the preparation of therapeutic agents for delivering to cells [P] . IL244945D0 . 2016-05-31

机译：阳离子脂质，包含该脂质的脂质制剂及其在制备用于递送至细胞的治疗剂中的用途

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An in vivo study349Exosomes from cardiomyocyte progenitor cells and mesenchymal stem cells stimulate angiogenesis in vitro and in vivo via EMMPRINEndothelium352Reciprocal regulation of GRK2 and bradykinin receptor stimulation modulate Ca2+ intracellular level in endothelial cells353The roles of bone morphogenetic proteins 9 and 10 in endothelial inflammation and atherosclerosis354The contribution of GPR55 to the L-alpha-lysophosphatidylinositol-induced vasorelaxation in isolated human pulmonary arteries355The endothelial protective ACE inhibitor Zofenoprilat exerts anti-inflammatory activities through H2S production356A new class of glycomimetic drugs to prevent free fatty acid-induced endothelial dysfunction357Endothelial progenitor cells to apoptotic endothelial cell-derived microparticles ration differentiatesas preserved from reduced ejection fractionheart failure358Proosteogenic genes are activated in endothelial cells of patients with thoracic aortic aneurysm359Endothelin ETB receptors mediate relaxing responses to insulin in pericardial resistance arteries from patients with cardiovascular disease (CVD)Smooth muscle and pericytes362CX3CR1 positive myeloid cells regulate vascular smooth muscle tone by inducing calcium oscillations via activation of IP3 receptors363A novel function of PI3Kg on cAMP regulation, role in arterial wall hyperplasia through modulation of smooth muscle cells proliferation364NRP1 and NRP2 play important roles in the development of neointimal hyperplasia in vivo365Azithromycin induces autophagy in aortic smooth muscle cellsCoagulation, thrombosis and platelets368The real time in vivo evaluation of platelet-dependent aldosterone prothrombotic action in mice369Development of a method for in vivo detection of active thrombi in mice370The antiplatelet effects of structural analogs of the taurine chloramine371The influence of heparin anticoagulant drugs on functional state of human platelets372Regulation of platelet aggregation and adenosine diphosphate release by d dimer in acute coronary syndrome (in vitro study)Oxygen sensing, ischaemia and reperfusion375Sirtuin 5 mediates brain injury in a mouse model of cerebral ischemia-reperfusion376Abscisic acid: a new player in cardiomyocyte protection from ischaemia?377Protective effects of ultramicronized palmitoylethanolamide (PEA-um) in myocardial ischaemia and reperfusion injury in vivo378Identification of stem cell-derived cardiomyocytes using cardiac specific markers and additional testing of these cells in simulated ischemia/reperfusion system379Single-dose intravenous metformin treatment could afford significant protection of the injured rat kidney in an experimental model of ischemia-reperfusion380Cardiotoxicity of long acting muscarinic receptor antagonists used for chronic obstructive pulmonary disease381Dependence antioxidant potential on the concentration of amino acids382The impact of ischemia-reperfusion on physiological parameters,apoptosis and ultrastructure of rabbit myocardium with experimental aterosclerosisMitochondria and energetics385MicroRNA-1 dependent regulation of mitochondrial calcium uniporter (MCU) in normal and hypertrophied hearts386Mitochondrial homeostasis and cardioprotection: common targets for desmin and aB-crystallin387Overexpression of mitofusin-2 (Mfn2) and associated mitochondrial dysfunction in the diabetic heart388NO-dependent prevention of permeability transition pore (MPTP) opening by H2S and its regulation of Ca2+ accumulation in rat heart mitochondria389G protein coupled receptor kinase 2 (GRK2) is fundamental in recovering mitochondrial morphology and function after exposure to ionizing radiation (IR)Gender issues392Sex differences in pulmonary vascular control; 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