METHODS FOR IDENTIFYING COMPOUNDS CAPABLE OF INHIBITING DEGRADATION OF PKM ZETA

摘要

The invention, among others relates to methods for identifying compounds capable of inhibiting degradation of PKM zeta, which e.g. comprise the steps of providing a test system for monitoring the degradation of PKM zeta, and determining whether a given test compound leads to a reduced degradation of PKM zeta in said test system; and/or comprise a step of determining whether a given test compound is capable of interfering with the proteasomal degradation of PKM zeta; or comprises a step of determining whether a given test compound is capable of interfering with the binding of a certain peptide, peptide derivative or peptide conjugate thereof to PKM zeta.