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Methods for identifying compounds capable of inhibiting degradation of PKM zeta
Methods for identifying compounds capable of inhibiting degradation of PKM zeta
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机译:鉴定能够抑制PKM Zeta降解的化合物的方法
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摘要
The invention, among others relates to methods for identifying compounds capable of inhibiting degradation of PKM zeta, which e.g. comprise the steps of providing a test system for monitoring the degradation of PKM zeta, and determining whether a given test compound leads to a reduced degradation of PKM zeta in said test system; and/or comprise a step of determining whether a given test compound is capable of interfering with the proteasomal degradation of PKM zeta; or comprises a step of determining whether a given test compound is capable of interfering with the binding of a certain peptide, peptide derivative or peptide conjugate thereof to PKM zeta.
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