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Apparatus and method for the detection of localised fluctuations of ionic charge during a chemical reaction by the use of ion sensitive field effect transistors
Apparatus and method for the detection of localised fluctuations of ionic charge during a chemical reaction by the use of ion sensitive field effect transistors
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机译:通过使用离子敏感场效应晶体管检测化学反应过程中离子电荷局部波动的装置和方法
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摘要
Sensor and method to detect localised fluctuations of ionic charge indicating events occuring during a chemical reaction, the sensing apparatus comprising an ion sensitive field effect transistor arranged to generate an electrical output signal in response to localised fluctuations of ionic charge at or adjacent the surface of the transistor, and means for detecting the electrical output signal from the field effect transistor is provided with a polymerase linked layer and the chemical reaction is DNA synthesis, and the localised fluctuations of ionic charge indicate the insertion of di-deoxynucleotide triphosphates and deoxynucleotide triphosphates by detecting a change of hydronium ions with a sensitive Si 3N4 layer of the field effect transistor.
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